guggal sterone

Guggal Sterone

Contents

"How To Improve Your Cold Symptoms By 535%  and Reduce The Risk of  Colds By 2.1X"

Click to Read

 Description of Guggal Sterone

Guggal Sterone is the resin of Mukul myrrh tree, a small, thorny plant found predominantly in the rocky, dry regions of India. Gum Guggulu, the yellowish resin produced in the stem of the Commiphora mukul tree is obtained by tapping the tree throughout the year. This resin is the source of the active components, Z-guggulsterone and E-guggulsterone as well as another eight steroids, acids, several aromatic acids, terpenes, and fatty acid alcohols. Some components seem to focus on cholesterol reduction activity, some are anti-inflammatories and some appear to work synergistically.

The use of Guggal Sterone was first documented 3000 years ago and it continues to play a major role in Ayurvedic medicine. Because Guggal sterone has been so venerated in India, it has become one of the more famous therapeutic herbs and is now used all over the world. It is reputed to have carminative, antispasmodic, diaphoretic, antisuppurative, emmenagogue (menstrual stimulant) and aphrodisiac qualities and has been used to treat conditions as wide-ranging as ulcers, tonsilitis, hay fever, urinary and thyroid conditions and of course, cholesterol problems.

In 1960, at the Banares Hindu University and subsequently at other Indian research centers, significant investigation began in an effort to scientifically quantify what tradition has held as the benefits of this ancient herbal therapy. Ancient Ayurvedic texts tell us that the therapeutic range of this herb is very systemic or wide-based, effecting primarily the immune system and the circulatory system. Traditionally, Guggal sterone is often mixed with herbs with a more specific range of activity to bring a more comprehensive approach to the patient, however, the primary interest of current research has been the control of hyperlipidemia or elevated blood cholesterol because heart disease is the greatest health threat in western civilizations.

Key Uses of Guggal Sterone

  • High Cholesterol
  • Anti-inflammatory
  • Heart disease
  • Immune Support
  • Anti-oxidant
  • Clinical Applications of Guggal Sterone

    Cholesterol controlling - Guggal Sterone helps the circulatory system to maintain a healthy HDL to LDL ratio.

    Cardiovascular support - Helps to prevent blood platelet aggregation; dissolves blood clots.

    Immune modulating -Guggul Sterone stimulates the activity of white blood cells in the body, contributing to the build-up of the immune system and protecting the body against infections.

    Anti oxidant activity- Guggul Sterone also exhibit significant antioxidant activity especially in the cardiovascular system where it helps to prevent damage to the arteries and heart muscle.

    How Guggal Sterone Works

    Cardiovasculat health: There is evidence that Z-guggalsterone functions as a thyroid stimulating agent. These are known to also reduce serum lipid levels. Additionally, Guggal sterone exerts a regulatory effect on the biosynthesis of cholesterol,. It has been shown to lower triglycerines and LDL and it acts in the liver effecting the rapid break-down and elimination of LDL from the body. It also elevates HDL. These functions all work to control and balance cholesterol levels without the side effects normally experienced with pharmaceuticals. There are also indications that Guggal sterone helps to prevent blood platelet aggregation and is instrumental in dissolving blood clots. Its anti-inflammatory action also helps reduce risk of strokes and heart attacks.

    Immune system regulation: Research shows that Guggal Sterone increases the production of white blood cells throughout the body, helping boost the immune system.

    Anti-oxidant: Guggal Sterone is instrumental in sustaining higher levels of the powerful free radical scavenger-enzyme, Superoxide dismutase.

    Safety of Guggal Sterone

    In many clinical trials, Guggal Sterone has show virtually no serious side effects and is generally considered safe for use in adults.

    Precautions of Guggal Sterone

    Patients with heart diseases or on thyroid medication should use this herb with precaution only after discussing with their doctors.  It acts as a uterine stimulant and therefore not advisable to be used during pregnancy.

    Recommended Amounts of Guggal Sterone

    Because herbs also contain active chemical substances which can and will interact with others, no herb or drug should be taken without first consulting with one's physician.

    The recommended starting dosage of Guggul Sterone is 25mg, 3 times per day or 50mg twice a day.

    Guggal Sterone Research

    1) Agarwal RC, Singh SP, Saran RK, et al. Clinical trial of gugulipid--a new hypolipidemic agent of plant origin in primary hyperlipidemia. Indian J Med Res 1986;84:626-634.

    2) Amma MK, Malhotra N, Suri RK, et al. Effect of oleoresin of gum guggul (Commiphora mukul) on the reproductive organs of female rat. Indian J Exp Biol 1978;16(9):1021-1023.

    3) Antonio J, Colker CM, Torina GC, et al. Effects of a standardized guggulsterone phosphate supplement on body composition in overweight adults: A pilot study. Curr Ther Res 1999;60:220-227.

    4) Arora RB, Kapoor V, Gupta SK, et al. Isolation of a crystalline steroidal compound from Commiphora mukul & its anti-inflammatory activity. Indian J Exp Biol 1971;9(3):403-404.

    5) Arora RB, Taneja V, Sharma RC, et al. Anti-inflammatory studies on a crystalline steroid isolated from Commiphora mukul. Indian J Med Res 1972;60(6):929-931.

    6) Baldwa VS, Sharma RC, Ranka PC, et al. Effect of Commiphora mukul (guggul) on fibrinolytic activity and platelet aggregation in coronary artery disease. Rajas Med J 1980;19(2):84-86.

    7) Beg M, Singhal KC, Afzaal S. A study of effect of guggulsterone on hyperlipidemia of secondary glomerulopathy. Indian J Physiol Pharmacol 1996;40(3):237-240.

    8) Bhatt AD, Dalal DG, Shah SJ, et al. Conceptual and methodologic challenges of assessing the short-term efficacy of Guggulu in obesity: data emergent from a naturalistic clinical trial. J Postgrad Med 1995;41(1):5-7.

    9) Bordia A, Chuttani SK. Effect of gum guggulu on fibrinolysis and platelet adhesiveness in coronary heart disease. Indian J Med Res 1979;70:992-996.

    10) Brown D, Austin S. Hyperlipidemia and Prevention of Coronary Artery Disease. Seattle, WA: NPRC, 1997, 4-6.

    11) Cui J, Huang L, Zhao A, et al. Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump. J Biol Chem 2003;278(12):10214-10220.

    12) Dalvi SS, Nayak VK, Pohujani SM, et al. Effect of gugulipid on bioavailability of diltiazem and propranolol. J Assoc Physicians India 1994;42(6):454-455.

    13) Das Gupta RD. Gugulipid: pro-lipaemic effect. J Assoc Physicians India 1990;38(8):598.

    14) Das Gupta R. Gugulipid: pro-lipaemic effect. J Assoc Physicians India 1990;38(12):346.

    15) Dogra J, Aneja N, Saxena VN. Oral gugulipid in acne vulgaris management. Ind J Dermatol Venereol Leprol 1990;56(1):381-383.

    16) Duwiejua M, Zeitlin IJ, Waterman PG, et al. Anti-inflammatory activity of resins from some species of the plant family Burseraceae. Planta Med 1993;59(1):12-16.

    17) Gaur SP, Garg RK, Kar AM, et al. Gugulipid, a new hypolipidaemic agent, in patients of acute ischaemic stroke: effect on clinical outcome, platelet function and serum lipids. Asia Pacif J Pharm 1997;12:65-69.

    18) Ghorai M, Mandal SC, Pal M, et al. A comparative study on hypocholesterolaemic effect of allicin, whole germinated seeds of bengal gram and guggulipid of gum gugglu. Phytother Res 2000;14(3):200-202.

    19) Gopal K, Saran RK, Nityanand S, et al. Clinical trial of ethyl acetate extract of gum gugulu (gugulipid) in primary hyperlipidemia. J Assoc Physicians India 1986;34(4):249-251.

    20) Gujral ML, Sareen K, Reddy GS, et al. Endocrinological studies on the oleo resin of gum guggul. Indian J Med Sci 1962;16:847-851.

    21) Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17(1):1-12.

    22) Jain JP. Clinical assessment of the value of oleo-resin of Commiphora mukul (Guggul) in obesity and hyperlipidemia. ICMR Bull 1980;10:83-84.

    23) Kesava RG, Dhar SC. Effect of a new non-steroidal anti-inflammatory agent on lysosomal stability in adjuvant induced arthritis. Ital J Biochem 1987;36(4):205-217.

    24) Kesava RG, Dhar SC, Singh GB. Urinary excretion of connective tissue metabolites under the influence of a new non-steroidal anti-inflammatory agent in adjuvant induced arthritis. Agents Actions 1987;22(1-2):99-105.

    25) Kishore P, Devi Das KV, Banarjee S. Clinical studies on the treatment of Amavata-Rheumatoid arthritis with Sunthi-Guggulu. J Res Ayur Siddha 1982;3(3-4):133-146.

    26) Kotiyal JP, Bisht DB, Singh DS. Double blind cross-over trial of gum guggulu (Commiphora mukul) Fraction A in hypercholesterolemia. J Res Indian Med Yoga Hom 1979;14(2):11-16.

    27) Kotiyal JP, Singh DS, Bisht DB. Gum guggulu (Commiphora mukul) fraction 'A' in obesity -- a double-blind clinical trial. J Res Ayur and Siddha 1985;6(1,3,4):20-35.

    28) Kuppurajan K, Rajagopalan SS, Koteswara Rao T, et al. Effect of guggulu (Commiphora mukul-Engl) on serum lipids in obese subjects. J Res Indian Med 1973;8(4):1-8.

    29) Kuppurajan K, Rajagopalan SS, Rao TK, et al. Effect of guggulu (Commiphora mukul--Engl.) on serum lipids in obese, hypercholesterolemic and hyperlipemic cases. J Assoc Physicians India 1978;26(5):367-373.

    30) Mahesh S, Pandit M, Hakala C. A study of Shuddha Guggulu on rheumatoid arthritis. Rheumatism 1981;16(2):54-67.

    31) Majumdar KA. A clinical study of R-Arthritis with A-Compound - a herbal formulation. Rheumatism 1984;19(3):66-74.

    32) Majumdar KA. Role of gum guggulu with gold in rheumatic and other allied disorders. Rheumatism 1984;20(1):9-15.

    33) Malhotra SC, Ahuja MM. Comparative hypolipidaemic effectiveness of gum guggulu (Commiphora mukul) fraction 'A', ethyl-P-chlorophenoxyisobutyrate and Ciba-13437-Su. Indian J Med Res 1971;59(10):1621-1632.

    34) Malhotra SC, Ahuja MM, Sundaram KR. Long term clinical studies on the hypolipidaemic effect of Commiphora mukul (Guggulu) and clofibrate. Indian J Med Res 1977;65(3):390-395.

    35) Mester L, Mester M, Nityanand S. Inhibition of platelet aggregation by "guggulu" steroids. Planta Med 1979;37(4):367-369.

    36) Nityanand S, Srivastava JS, Asthana OP. Clinical trials with gugulipid. A new hypolipidaemic agent. J Assoc Physicians India 1989;37(5):323-328.

    37)Nityanand S, Kapoor NK. Hypocholesterolemic effect of Commiphora mukul resin (Guggal). Indian J Exp Biol 1971;9:367-77.

    38)Satyavati GV. Gum guggul (Commiphora mukul)-The success of an ancient insight leading to a modern discovery. Indian J Med 1988;87:327-35.

    39) Sharma K, Puri AS, Sharma R, et al. Effect of gum guggul on serum lipids in obese subjects. J Res Indian Med Yoga Hom 1976;11(2):132.

    40) Sharma JN, Sharma JN. Comparison of the anti-inflammatory activity of Commiphora mukul (an indigenous drug) with those of phenylbutazone and ibuprofen in experimental arthritis induced by mycobacterial adjuvant. Arzneimittelforschung 1977;27(7):1455-1457.

    41) Sidhu LS, Sharma K, Puri AS, et al. Effect of gum guggul on body weight and subcutaneous tissue folds. J Res Indian Med Yoga Hom 1976;11(2):16-22.

    42) Singh RP, Singh R, Ram P, et al. Use of Pushkar-Guggul, an indigenous antiischemic combination, in the management of ischemic heart disease. Int J Pharmacog 1993;31(2):147-160.

    43) Singh BB, Mishra L, Aquilina N, et al. Usefulness of guggul (Commiphora mukul) for osteoarthritis of the knee: An experimental case study. Altern Ther Health Med 2001;7(2):120, 112-114.

    44) Singh GB, Atal CK. Pharmacology of an extract of salai guggal ex-Boswellia serrata, a new non-steroidal anti-inflammatory agent. Agents Actions 1986;18(3-4):407-412.

    45) Singh RB, Niaz MA, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther 1994;8(4):659-664.

    46)Singh K, Chander R, Kapoor NK. Guggulsterone, a potent hypolipidaemic, prevents oxidation of low density lipoprotein. Phytother Res 1997;11:291-4.

    47) Sosa S, Tubaro R, Della Loggia R, et al. Anti-inflammatory activity of Commiphora mukul extracts. Pharmacol Res 1993;27(suppl 1):89-90.

    48) Szapary PO, Wolfe ML, Bloedon LT, et al. Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial. JAMA 2003;290(6):765-772.

    49) Thappa DM, Dogra J. Nodulocystic acne: oral gugulipid versus tetracycline. J Dermatol 1994;21(10):729-731.

    50) Tripathi SN, Upadhyay BN. A clinical trial of Commiphora mukul in the patients of ischaemic heart disease. J Mol and Cell Cardiol 1978;10(suppl 1):124.

    51) Tripathi SN, Gupta M, Sen SP, et al. Effect of a keto-steroid of Commifora mukul L. on hypercholesterolemia & hyperlipidemia induced by neomercazole & cholesterol mixture in chicks. Indian J Exp Biol 1975;13(1):15-18.

    52) Tripathi YB, Malhotra OP, Tripathi SN. Thyroid stimulating action of Z-guggulsterone obtained from Commiphora mukul. Planta Med 1984;(1):78-80.

    53) Tripathi YB, Tripathi P, Malhotra OP, et al. Thyroid stimulatory action of (Z)-guggulsterone: mechanism of action. Planta Med 1988;54(4):271-277.

    54) Upadhyaya BN, Tripathi SN, Dwivedi LD. Hypocholesterolemic and hypolipidemic action of gum guggulu in patients of coronary heart disease. J Res Indian Med Yoga Hom 1976;11(2):1-8.

    55) Urizar NL, Liverman AB, Dodds DT et al. A natural product that lowers cholesterol as an antagonist ligand for the FXR. Science (Science Express Reports) 2002 (May 3).

    56) Verma SK, Bordia A. Effect of Commiphora mukul (gum guggulu) in patients of hyperlipidemia with special reference to HDL-cholesterol. Indian J Med Res 1988;87:356-360.

    57) Wu J, Xia C, Meier J, et al. The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor. Mol Endocrinol 2002;16(7):1590-1597.

     

     

     

     

     

    .

     


    Amazing Natural Health
    ($24.95) FREE

    Name
    Email
    We will never provide your information to a 3rd party. You can easily unsubscribe at any time.
    If you would like the printed edition for $24.95 please let us know.

    > Colds
    > Flu - Influenza
    > Pneumonia
    > Sinusitis

    20 Years of Clinical Research

    One of the best ways to stop cold/flu season viruses is to take action at the first sign of symptoms. This potent combination  is little known in the US but widely used by doctors in Scandinavia. For me it stops cold & flu in about a day.

    Have a Health Question?
    Do you have a health question that you have been meaning to ask a Doctor. It could be about anything.  Just Ask.  

    Featured Product Zymosine
    A Safe Alternative to Pain Drugs. Unique Triple Power Formula safely relieves pain, promotes healthy flexible joints and speeds healing of common strains, sprains & bruises.
     
    Claims made on this site have not been evaluated by the United States Food and Drug Administration and are for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. Products or supplements discussed are not intended to diagnose, treat, cure or prevent disease.

    © 2004 Boulder Natural Labs, LLC. All rights reserved.