How
Bromelain Works
Bromelain appears to inhibit a
number of aspects involved in the Coagulation Cascade, a
biochemical process that triggers blood clotting and inflammation
at wound sites and/or in the body in general. It has been shown to
interfere with the development of fibrin among the different blood
components resulting in a subsequent decrease of platelet
aggregation or blood clots, and contributing to improved
circulation.
Further, Bromelain inhibits
inflammation and associated pain by inhibiting pro-inflammatory
mediators. By keeping these inflammatory biochemicals which
trigger swelling, redness, heat and pain from moving into and
constricting tissues, inflammation is reduced, circulation
improves and tissues start to heal. It also appears to have the
advantage of selectively controlling some of the biochemical
causes of pain and inflammation rather than the often-uncontrolled
effect of NSAIDS. Bromelain has also shown in animal studies, to
have a stimulating effect on the development of plasmin which
contributes to tissue healing and which also inhibits some of the
precursors to the coagulation process.
Bromelain research has shown
great potential in other areas of treatment. It appears to
significantly stimulate the immune system by promoting the
production of cytokines in cells. It also appears to potentiate
antibiotics and supplements such as glucosamine and preliminary
testing indicates it may have a significant anti-tumor effect.
Bromelain Safety
Bromelain is considered safe even at
high dosages. No toxicity was report in a 6 month study where dogs
750/mg/Kg daily. The typical dose for humans is between 450 and
2,000 mg per day. Some reported
allergies have been report with Bromelain. These can occur in
individuals with allergies to Pineapple or other members of the Bromeliaceae family.
A small percentage of people who are sensitive to
honeybee venom, latex, birch pollen, carrot, celery, fennel,
cypress pollen, grass pollen, papain have also experience
allergies to bromelain.
Bromelain Side Effects
Because of Bromelain's
anti-coagulant properties, patients using anti-coagulant
medications should consult with their physicians before using.
Other reported side effects are
stomach upset and diarrhea, increased heart rate, nausea,
vomiting, irritation of mucus membranes, and menstrual problems.
Not recommended for pregnant women due to lack of
research.
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